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KMID : 0861020090240010121
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Korea Journal of Herbology
2009 Volume.24 No. 1 p.121 ~ p.131
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Effects of Herbal Composition and Fermented Cervi Pantotrichum Cornu on Longitudinal Bone Growth in Adolescent Male Rats
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Lee Se-Na
Son Jae-Bong
Sohn Jong-Hee
Kim Wan-Gi
Lee Sang-Jun
Lee Pyeong-Jae
Leem Kang-Hyun
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Abstract
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Objectives: This study was designed to investigate the effects of herbal composition and fermented Cervi Pantotrichum Cornu on the growth of longitudinal bone in the adolescent male rats.
Methods: Longitudinal bone growth was measured by fluorescence microscopy. To examine the effects on the growth plate metabolism, the total height of growth plate and the induction of local insulin-like growth factor-1 (IGF-1) and bone morphogenetic protein-2 (BMP-2) were measured.
Results: The herbal composition treatment enhanced longitudinal bone growth and total heght of growth plate and promoted the induction of local IGF-1 and BMP-2 of growth plate.
Conclusions: This study showed that the herbal composition have the effect of bone growth in adolescent rats and might be used for the growth delayed adolescent and inherent growth failure patient.
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KEYWORD
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Herbal composition, Cervi Pantotrichum Cornu, Longitudinal bone growth, Insulin-like growth factor-1, Bone morphogenetic protein-2, Growth plate
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